Assessment of the reporting of harms in systematic reviews focused on hallucinogens: A cross-sectional study.
Journal of psychopharmacology (Oxford, England) February 1, 2026 Kaylin Ray, Kaylyn Jade Rowsey, Lauren Kramer et al.
Harms are largely underreported in systematic reviews of hallucinogen use, even when reviews list harms as a primary or secondary outcome. In an analysis of 32 systematic reviews, only 2 (6.3%) reported predetermined methods to grade, collect, or statistically analyze harms data. A significant relationship was found between completeness of harm reporting and whether harms were listed as a primary or secondary outcome. The inadequate reporting is unlikely to provide credible evidence for evaluating benefit-harm trade-offs, and steps should be taken to improve harms reporting in studies of hallucinogen use.