Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province; Engineering Technology Research Center for detection and application of brain function of Henan Province; Engineering Research Center of medical imaging intelligent diagnosis and treatment of Henan Province; Key Laboratory of magnetic resonance and brain function of Henan Province; Key Laboratory of brain function and cognitive magnetic resonance imaging of Zhengzhou; Key Laboratory of Imaging Intelligence Research medicine of Henan Province; Henan Engineering Research Center of Brain Function Development and Application.
1 paper in the library · 1 citation · publishing 2025
A systematic review of 18 multimodal neuroimaging studies (440 depressed individuals, 174 healthy controls) mapped brain locations linked to ketamine's antidepressant effects onto a functional brain network. The network primarily involved regions of the default mode, ventral attention, and frontoparietal networks. This network was robust under parameter perturbations and leave-one-study-out validation, and was specific to depression compared to other mental disorders. A ketamine-specific circuit, including the subgenual cingulate cortex and dorsolateral prefrontal cortex, overlapped with optimal brain stimulation sites for depression. These findings reconcile inconsistent results and suggest a network-level mechanism for ketamine's therapeutic effects.