Functional connectivity of the amygdala subregions and the antidepressant effects of repeated ketamine infusions in major depressive disorder.
European psychiatry : the journal of the Association of European Psychiatrists April 4, 2024 Haiyan Liu, Chengyu Wang, Xiaofeng Lan et al. 7 citations
Abnormal connectivity between a specific amygdala subregion (the left laterobasal amygdala) and the left precuneus in people with major depressive disorder is linked to how well ketamine treatment works. After six doses of ketamine (0.5 mg/kg), differences in connectivity changes between responders and nonresponders appeared in the bilateral centromedial amygdala with the left orbital part of the superior frontal gyrus and in the left laterobasal amygdala with the right middle frontal gyrus. A baseline difference in connectivity between the left laterobasal amygdala and the right superior/middle temporal gyrus predicted the antidepressant effect on Day 13, suggesting that ketamine may improve symptoms by regulating amygdala subregion networks.