Acute complications and treatment in critically ill patients with 3,4-methylenedioxymetamfetamine intoxication: a 10-year retrospective observational study in an intensive care unit in an Amsterdam hospital.
Clinical toxicology (Philadelphia, Pa.) March 1, 2025 Mirte J Zuidema, Elles Reimerink, Dena Akhoundzadeh et al. 1 citation
Among critically ill patients with MDMA intoxication admitted to an intensive care unit in Amsterdam between 2010 and 2020, the most common reason for admission was a threatened airway due to trismus (jaw clenching), occurring in 47% of cases, which often led to respiratory acidosis. Hyponatraemia occurred in 39% of patients, and hyperthermia in 11%. Patients with hyperthermia frequently developed severe complications such as rhabdomyolysis, acute kidney injury, and liver failure. The median correction of serum sodium was greater than European guidelines recommend, but no osmotic demyelination was reported. Overall, 4% of the 74 patients died, though most recovered fully.