Brain-derived neurotrophic factor (BDNF) changes in rodent models of schizophrenia induced by ketamine: a systematic review.
Naunyn-Schmiedeberg's archives of pharmacology February 20, 2025 Atefeh Motamedi-Manesh, Mahdieh Farzin Asanjan, Hamed Fallah et al. 6 citations
A systematic review of 17 rodent studies found that ketamine's effects on brain-derived neurotrophic factor (BDNF) depend on treatment duration, species, and sex. Sub-chronic and chronic ketamine treatment decreased BDNF or had no effect in rats, and decreased BDNF in mice. Acute ketamine treatment commonly increased BDNF. One study reported inconsistent BDNF changes between male and female rats. Due to high methodological variability, there is currently no standardized method for using ketamine as a rodent model of schizophrenia.