REM density predicts rapid antidepressant response to ketamine in individuals with treatment-resistant depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology May 1, 2025 Mina Kheirkhah, Wallace C Duncan, Qiaoping Yuan et al. 6 citations
People with treatment-resistant depression show higher REM density in the first REM period and shorter REM latency than healthy volunteers, while total night REM density does not differ. Ketamine treatment reduces REM density in the first REM period but does not change total night REM density or REM latency. Baseline REM density in the first REM period moderately predicts whether a person will respond to ketamine, with higher levels indicating greater likelihood of response. This marker could help identify individuals most likely to benefit from ketamine therapy.