Involvement of N-methyl-D-aspartate receptor GluN2C/GluN2D subunits in social behavior impairments in mice exposed to social defeat stress as juveniles.
Journal of pharmacological sciences March 1, 2025 Mikio Yoshida, Hikari Katada, Yuya Isozumi et al. 4 citations
In mice exposed to social defeat stress as juveniles, social behavior impairments were linked to elevated levels of GluN2C and GluN2D proteins in the prefrontal cortex. Acute administration of PPDA, a GluN2C/GluN2D antagonist, or ketamine, a non-competitive NMDA receptor antagonist, reduced these impairments. The effect of ketamine was partially blocked by CIQ, a GluN2C/GluN2D potentiator. Activation of GluN2C- and/or GluN2D-containing NMDA receptors appears to contribute to social behavior deficits from juvenile stress, and these subunits may be involved in ketamine's therapeutic action. Targeting these subunits could offer new treatment strategies for stress-related psychiatric disorders in adolescents.