Efficacy of fluoxetine and (R,S)-ketamine in attenuating conditioned fear behaviors in male mice.
The Journal of pharmacology and experimental therapeutics January 1, 2025 Megan Wells, Jan Hoffmann, Autumn Stage et al. 1 citation
Combining a single dose of ketamine with chronic fluoxetine (Prozac) reduces fear memory in mice two weeks after fear conditioning, though it does not reduce anxiety or fear generalization in an open field test. Fluoxetine alone was most effective at reducing fear generalization. Current PTSD medications lead to symptom remission in fewer than 30% of patients. This study offers preliminary support for a more effective therapeutic option for stress-related disorders.