Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus.
Progress in neurobiology March 1, 2025 Odra Santander, Sebastián B Arredondo, Francisca García-Rojas et al. 3 citations
Chronic ketamine administration during adolescence in mice produces long-lasting changes in synaptic integration in the dorsal hippocampal dentate gyrus, specifically expanding the temporal window for inputs from the inner molecular layer but not the medial perforant path. Ketamine also reduces inhibitory synaptic efficacy, likely by decreasing the number and function of parvalbumin-positive interneurons, thereby altering the excitatory/inhibitory balance. These findings suggest that adolescent ketamine exposure strongly affects inhibitory synaptic function mediated by parvalbumin neurons, ultimately impacting synaptic integration in adulthood and may help explain the heightened vulnerability of the adolescent brain.