Zebra_K, a kinematic analysis automated platform for assessing sensitivity, habituation and prepulse inhibition of the acoustic startle response in adult zebrafish.
The Science of the total environment January 1, 2025 Marija Stevanović, Niki Tagkalidou, Cristiana Roberta Multisanti et al. 15 citations
A new automated platform, Zebra_K, measures the acoustic startle response (ASR), its habituation, and prepulse inhibition (PPI) in adult zebrafish. The ASR in adults shows a single short-latency C-bend similar to larvae. Females had higher responsiveness, lower habituation, and lower PPI than males. The NMDA-receptor antagonist ketamine increased responsiveness, decreased habituation, and abolished PPI. These findings support using adult zebrafish to study environmental effects on ASR plasticity.