5-HT1B receptor activation produces rapid antidepressant-like effects in rodents.
Pharmacology, biochemistry, and behavior February 1, 2025 Erin A Clark, Lien Wang, Taleen Hanania et al. 5 citations
Activating the 5-HT1B receptor with the drug CP-94253 produces rapid and sustained antidepressant-like effects in rodents, similar to ketamine. In mice, CP-94253 reduced immobility in the forced swim test and showed a strong antidepressant signature in a behavioral screening platform. Effects lasted at least 24 hours after a single dose in both naive rats and those receiving chronic interferon alpha treatment. The drug also enhanced hippocampal long-term potentiation measured 24 hours later. In mice subjected to chronic social defeat stress, antidepressant-like effects appeared within 1 hour in the tail suspension test and within 24 hours in the sucrose preference test.