The effect of a subclinical dose of esketamine on depression and pain after cesarean section: A prospective, randomized, double-blinded controlled trial.
Medicine November 1, 2024 Xiangqian Wan, Ming Li, Xiantao Li et al. 8 citations
A subclinical dose of esketamine (0.25 mg/kg) given after umbilical cord clamping during elective cesarean sections did not reduce the incidence of postpartum depression at 14 days postpartum, as measured by the Edinburgh Postnatal Depression Scale. However, it did significantly lower postoperative pain scores on the Visual Analog Scale at 4 and 24 hours after surgery. The treatment group experienced temporary increases in adverse reactions and sedation scores five minutes after administration. The findings suggest esketamine may offer short-term pain relief without preventing postpartum depression.