Interventional approaches to treatment resistant depression (DTR) in children and adolescents: A systematic review and meta-analysis.
Journal of affective disorders December 15, 2024 Ethan Faries, Landon A Mabe, Ronald L Franzen et al. 13 citations
Repetitive transcranial magnetic stimulation (rTMS) produced significantly larger reductions in depression scores than electroconvulsive therapy (ECT) in adolescents with treatment-resistant depression, and potentially larger reductions than ketamine. A meta-analysis of 10 observational studies examined standardized mean differences in depression scores for youth aged 10-24 treated with ECT, rTMS, or ketamine. ECT had a significantly lower standardized mean difference of 1.99. No significant difference was found between ECT and ketamine. The comparison of ketamine versus rTMS suggested a potential difference favoring rTMS. rTMS shows promise as a first-line treatment for pediatric treatment-resistant depression due to its favorable side effect profile compared to ECT.