The Involvement of the Serotonergic System in Ketamine and Fluoxetine Combination-induced Cognitive Impairments in Mice.
The Eurasian journal of medicine June 1, 2024 Emre Uyar, Meral Erdinç, İlker Kelle et al.
Low-dose ketamine alone does not significantly affect emotional memory encoding in mice, but combining it with the antidepressant fluoxetine disrupts memory consolidation. Fluoxetine alone impairs memory acquisition, though this effect normalizes during later consolidation and retrieval. The serotonergic system appears involved: increased serotonin transmission may contribute to ketamine's memory-impairing and neurotoxic effects. Histopathological evidence shows neurodegeneration in all groups receiving ketamine. Hippocampal oxidative stress markers were unchanged across treatments.