Ketamine Induced Acute Systolic Heart Failure.
European journal of case reports in internal medicine January 1, 2024 Fares Saliba, Jonathan Mina, Laurence Aoun et al. 4 citations
A 28-year-old woman with a 14-year history of twice-weekly ketamine use developed acute systolic heart failure with an ejection fraction (EF) of 15%, dilated left ventricle, and severe valve leakage. After treatment with diuretics, metoprolol, and sacubitril/valsartan, her EF improved to 25% at two weeks and to 54% with normal heart size at four months. The case suggests ketamine use disorder can cause severe, reversible heart failure through direct negative inotropic effects. Clinicians should screen for ketamine use in young adults with unexplained acute systolic heart failure.