Subanesthetic S-ketamine does not acutely alter striatal dopamine transporter binding in healthy Sprague Dawley female rats.
Synapse (New York, N.Y.) July 1, 2024 Simone Larsen Bærentzen, Jakob Borup Thomsen, Majken Borup Thomsen et al. 1 citation
Acute administration of S-ketamine, a fast-acting antidepressant, did not alter dopamine transporter (DAT) availability in the striatum of healthy female rats, as measured by [18F]FE-PE2I PET imaging and [3H]GBR-12935 autoradiography. This negative result suggests that changes in DAT binding are not involved in S-ketamine's rapid antidepressant mechanism, though further research is needed.