Volumetric mesoscopic electrophysiology: a new imaging modality for the non-human primate.
bioRxiv : the preprint server for biology May 14, 2024 Tobias Teichert, László Papp, Ferenc Vincze et al. 1 citation preprint
A new recording method called MePhys uses 992 electrode contacts across 62 shafts implanted in a monkey hemisphere to measure brain activity at a mesoscopic scale, bridging the gap between fMRI, EEG, and microelectrode techniques. By analyzing over 300,000 simultaneously recorded electrode pairs, the method reveals that a subanesthetic dose of ketamine, which mimics aspects of psychosis, induces a pronounced state of functional disconnection and prevents the formation of stable large-scale intrinsic brain states. MePhys offers a complementary window into brain function with unique advantages and limitations.