Efficacy of addition of the anti-inflammatory, IV glutathione to standard ketamine IV therapy in major depressive disorder.
Psychiatry research July 1, 2024 Ladan Eshkevari, Michelle Sales, Christina Collins et al. 3 citations
Adding glutathione, an antioxidant, to standard ketamine infusion does not improve outcomes for people with major depressive disorder compared to ketamine alone. In a double-blind study with 30 patients split into two groups of 15, both groups showed significant drops in depression scores from day 1 to day 14, and from day 14 to day 28 for one measure, indicating the overall treatment was effective. However, there were no statistically significant differences between the groups over time. A sustained improvement in depressive symptoms lasted for 14 days after infusion in both groups.