Effects of esketamine on postoperative fatigue syndrome in patients after laparoscopic resection of gastric carcinoma: a randomized controlled trial.
BMC anesthesiology May 24, 2024 Xinru Lin, Xiaoxue Feng, Linxiao Sun et al. 21 citations
Perioperative esketamine reduces postoperative fatigue syndrome (POFS) after laparoscopic radical gastrectomy for gastric cancer. In a double-blind randomized trial, 133 patients received either standard anesthesia alone or with esketamine. The esketamine group had significantly lower Christensen fatigue scores on postoperative day 3 (estimated difference -0.70; 95% CI -1.37 to -0.03) and less fatigue on days 1 and 3. Patients who had total gastrectomy showed greater fatigue reduction with esketamine than those who had distal gastrectomy. Esketamine also reduced postoperative pain and improved sleep, with no increase in adverse events.