Efficacy and safety of esketamine for pediatric gastrointestinal endoscopy: a meta-analysis and trial sequential analysis.
Frontiers in pharmacology January 1, 2024 Yunfeng Yu, Juan Deng, Keke Tong et al. 8 citations
Adding esketamine to anesthesia for children undergoing gastrointestinal endoscopy shortens recovery time by about 2.3 minutes, reduces propofol needed by 0.7 mg/kg, and lowers the risk of involuntary movements by 59% and choking by 51%, while increasing heart rate and blood pressure. However, general doses raise dizziness risk by 98%. Low doses (≤0.3 mg/kg) provide the same benefits without increasing dizziness. Trial sequential analysis confirmed these findings are conclusive.