Comparison between dexmedetomidine and ketofol in the prevention of postoperative emergence delirium in pediatric patients undergoing orofacial cleft surgery: A randomized controlled trial.
Journal of anaesthesiology, clinical pharmacology January 1, 2025 Surabhi, Poonam Kumari, Amarjeet Kumar et al. 1 citation
In children undergoing orofacial cleft surgery, giving dexmedetomidine (0.3 μg/kg) before extubation reduced emergence delirium more effectively than a ketamine-propofol mixture (ketofol) or saline. Delirium incidence was 20% with dexmedetomidine, 29% with ketofol, and 49% with saline. Pain scores were also lower with dexmedetomidine. Both sedatives outperformed saline, but dexmedetomidine provided the best prevention of postoperative delirium and pain.