The Effect of Preprocedural Low-Dose Ketamine for Pain and Anxiety in Patients during Thoracic Epidural Catheterization.
Medicina (Kaunas, Lithuania) April 22, 2024 Onur Küçük, Esra Sarı, Musa Zengin et al. 2 citations
A low dose of intravenous ketamine (0.15 mg/kg) given three minutes before thoracic epidural catheterization reduces both pain and anxiety during the procedure more than a placebo. Among sixty patients randomly assigned to either ketamine or placebo, those receiving ketamine reported, on average, 9 mm lower pain scores and 10.6 mm lower anxiety scores on 100 mm visual analog scales during catheter insertion. More patients in the ketamine group did not recall the procedure and would consent to it again. Pain scores remained stable in the ketamine group, while they rose in the placebo group. The dose caused no significant side effects on breathing, blood pressure, or mental state.