Enhancing Cognitive Functions and Neuronal Growth through NPY1R Agonist and Ketamine Co-Administration: Evidence for NPY1R-TrkB Heteroreceptor Complexes in Rats.
Cells April 12, 2024 Carlos Arrabal-Gómez, Rasiel Beltran-Casanueva, Aracelis Hernández-García et al. 7 citations
A single dose combining a neuropeptide Y Y1 receptor agonist with ketamine enhanced memory consolidation and increased production of new neurons (neuroblasts) in the dorsal hippocampus of male rats, without affecting quiescent neural progenitors or astrocytes. The effects were linked to brain-derived neurotrophic factor and suggested the formation of NPY1R-TrkB heteroreceptor complexes, though this interaction requires further confirmation. The findings point to a potential therapeutic approach for neurodegenerative diseases.