Effects of intraoperative low-dose esketamine on postoperative pain after vestibular schwannoma resection: A prospective randomized, double-blind, placebo-controlled study.
British journal of clinical pharmacology August 1, 2024 Kaizheng Chen, Yaming Xie, Songyuan Chi et al. 6 citations
Low-dose esketamine given during surgery for vestibular schwannoma did not reduce pain at rest or with movement in the first 24 hours after the operation. The trial randomly assigned 90 adults to receive either 0.2 mg/kg of esketamine or a placebo after dural closure. Esketamine moderately increased brain activity as measured by the bispectral index for at least 30 minutes after administration, prolonged the time to removal of the breathing tube, and lowered the required dose of remifentanil at that point, but did not affect heart rate, blood pressure, or the time to regain spatial orientation. Rates of nausea and vomiting were similar between groups, and no hallucinations or excessive sedation occurred.