Combining brief recall and ketamine treatment prevents stress-primed methamphetamine memory reinstatement via heightening mPFC GABA activity.
European journal of pharmacology June 5, 2024 Li-Han Sun, Lung Yu, Ya-Hsuan Chan et al. 2 citations
A brief recall of methamphetamine-associated memory combined with ketamine treatment facilitated the extinction of that memory and made it resistant to stress-triggered reinstatement in animals. The combination increased glutamate metabotropic receptor 5 (mGluR5) in GABA neurons of the medial prefrontal cortex (mPFC). Chemogenetic experiments showed that activating mPFC GABA neurons preserved extinction and prevented stress-primed reinstatement, whereas inhibiting them restored vulnerability to reinstatement. The findings suggest that exciting mPFC GABA neurons plays a key role in the effects of brief recall plus ketamine on curbing stress-provoked drug seeking.