High-order brain interactions in ketamine during rest and task: A double-blinded cross-over design using portable EEG.
Research square March 21, 2024 Agustin Ibanez, Rubén Herzog, Florentine Barbey et al. 1 citation
Ketamine increases redundancy in brain dynamics, particularly in the alpha frequency band, and this effect is more pronounced during resting state and associated with dissociative experiences. In a double-blinded cross-over design with 30 male adults, racemic ketamine was compared to saline infusion. Higher-order interactions (HOI) computed from EEG data showed that ketamine boosted redundancy, especially for predictable stimuli in an auditory oddball task. These findings suggest that ketamine-induced shifts toward dissociation correlate with increased redundancy in neural signal interactions, highlighting the potential of complexity measures with portable EEG for monitoring pharmacological changes in consciousness.