Journal of analytical toxicology
March 21, 2022
Ruben Goncalves, Nadege Castaing, Karine Titier et al.
9 citations
A 55-year-old man died at home after a chemsex party. Toxicological analysis found high concentrations of the dissociative anesthetic methoxphenidine (MXP) in his femoral blood (606 µg/L), cardiac blood (254 µg/L), and hair (13 ng/mg). Traces of 3-methylmethcathinone (3-MMC) were also detected. Other drug concentrations were consistent with living subjects. This case highlights the risk of MXP poisoning during chemsex and underscores the need to include new psychoactive substances in postmortem toxicology screening.
Journal of pharmaceutical and biomedical analysis
June 15, 2024
Romain Magny, Bruno Mégarbane, Lucie Chevillard et al.
7 citations
A chronic user of GHB, 3-MMC, and methoxetamine lost consciousness during a chemsex session and was admitted to intensive care, recovering quickly. Analysis of ten plasma samples over 29.5 hours, plus urine, hair, and a seized crystal, using liquid and gas chromatography, mass spectrometry, and nuclear magnetic resonance, confirmed exposure to multiple drugs including GHB, two benzofurans, two cathinones, and a new psychoactive substance: deschloro-N-ethyl-ketamine (O-PCE), an arylcyclohexylamine. Molecular networking identified 27 O-PCE metabolites, some previously unreported. O-PCE had an elimination half-life of about 5 hours. Lipid metabolism was markedly altered, likely from polydrug use.