Effect of esketamine combined with pregabalin on acute postsurgical pain in patients who underwent resection of spinal neoplasms: a randomized controlled trial.
Pain September 1, 2024 Yang Zhou, Wanchen Sun, Yuxuan Fu et al. 9 citations
Moderate-to-severe acute postsurgical pain after spinal surgery can slow recovery. A combination of esketamine and pregabalin reduced the incidence of such pain from 60.5% to 27.3% in the first 48 hours after surgery, based on a randomized trial of 90 patients undergoing resection of spinal neoplasms. The odds ratio was 0.25, indicating a substantial benefit. However, mild dissociative symptoms occurred in 18.2% of the combination group versus none in the control group, suggesting the analgesic strategy carries this risk.