Toxicokinetics of MDMA and Its Metabolite MDA in Rats.
Fa yi xue za zhi February 25, 2024 Wei-Guang Yu, Qiang He, Zheng-Di Wang et al.
After a single injection of MDMA in rats, peak concentrations of MDMA and its metabolite MDA occurred at 5 minutes and 1 hour, respectively, and both were detectable up to 12 hours. After continuous daily administration over 7 days, peak times shifted to 30 minutes for MDMA and 1.5 hours for MDA, and the detection window shortened to 10 hours. The ratio of MDMA to MDA in plasma followed a nonlinear relationship with time, described by separate equations for single and continuous dosing. These toxicokinetic differences provide reference data for forensic identification of MDMA exposure.