Patient-reported outcomes on sleep quality and circadian rhythm during treatment with intravenous ketamine for treatment-resistant depression.
Therapeutic advances in psychopharmacology January 1, 2024 Raymond Yan, Tyler Marshall, Atul Khullar et al. 11 citations
Over a 4-week course of eight intravenous ketamine infusions, adults with treatment-resistant depression reported improved sleep quality and an earlier circadian rhythm. Sleep quality, measured by the Pittsburgh Sleep Quality Index, improved significantly, as did depressive symptoms. Circadian rhythm, measured by the Morningness-Eveningness Questionnaire, shifted earlier. Improvements in sleep duration and daytime dysfunction were also observed. The effect on sleep quality was more prominent in patients with mixed features of depression, while the circadian shift was more prominent in those without mixed features. The study was small and uncontrolled, so findings are preliminary.