Ketamine evoked disruption of entorhinal and hippocampal spatial maps
bioRxiv Preprint Server February 5, 2023 Francis Kei Masuda, Yanjun Sun, Emily A Aery Jones et al. 2 citations preprint
Ketamine, used as a fast-acting anesthetic and antidepressant, causes spatial cognition side effects such as out-of-body experiences and spatial memory impairments, but the underlying neural mechanisms were unclear. In mice navigating virtual and real environments, ketamine acutely disrupted and then re-organized spatial representations in the medial entorhinal cortex, increasing excitatory neuron firing rates and degrading temporal coordination between cell pairs. In the hippocampus, neurons encoding the animal's position were suppressed after ketamine. These findings suggest that disruption of spatial coding in the entorhinal-hippocampal circuit may underlie ketamine-induced changes in spatial cognition.