Acute effects of subanesthetic ketamine on cerebrovascular hemodynamics in humans: A TD-fNIRS neuroimaging study
bioRxiv Preprint Server January 6, 2023 Adelaida Castillo, Julien Dubois, Ryan M. Field et al. 3 citations preprint
Ketamine reduced brain-wide low-frequency fluctuations and decreased prefrontal global brain connectivity in healthy adults, while also increasing pulse rate and electrodermal activity. A combination of neural and physiological metrics may predict subjective mystical experiences and reductions in depressive symptoms. The study used time-domain functional near-infrared spectroscopy to measure acute brain dynamics after intramuscular ketamine (0.75 mg/kg) or placebo in 15 participants within a clinical setting, demonstrating the feasibility of this neuroimaging method for larger clinical studies on psychedelics.