Ketamine reverses chronic stress-induced behavioral changes via Ca2+-permeable AMPA receptors in mice
bioRxiv Preprint Server October 7, 2024 Joshua C. Flowers, Paige E. Vetter, McKennon J. Wiles et al. 2 citations preprint
Chronic stress disrupts AMPA receptor signaling in the hippocampus, contributing to anxiety, depression, and cognitive decline. Low-dose ketamine rapidly increases GluA1-containing, GluA2-lacking calcium-permeable AMPA receptors (CP-AMPARs) in hippocampal neurons, enhancing glutamatergic synaptic strength and reducing anxiety- and depression-like behaviors in naïve animals. Ketamine may also protect against chronic stress effects, but whether CP-AMPARs mediate its antistress actions remains unknown.