Ecstasy as a Potential Cause for Diffuse ST Elevation in a 27-Year-Old Healthy Male: A Case Report.
Cureus June 1, 2025 Rabih Nasrallah, Amin Ossaily, Mazen Al Hammoud et al. 2 citations
A 27-year-old previously healthy man developed oppressive chest pain and diffuse ST-segment elevation on his electrocardiogram several days after using ecstasy (MDMA). His troponin level was normal, and coronary angiography showed no blockages, consistent with coronary vasospasm rather than a heart attack. MDMA increases serotonin, dopamine, and noradrenaline, which can trigger vasospasm. Though conclusive evidence linking MDMA to acute coronary syndrome is limited, cases of transient vasospasm and thrombosis have been reported, indicating that prompt evaluation is needed for chest pain after ecstasy use.