Comparison of the effects of esketamine/midazolam and remifentanil/midazolam on respiratory mechanics in mechanically ventilated patients with acute respiratory distress syndrome.
BMC anesthesiology July 5, 2025 Dujuan Qiao, Wei Liu, Huanjia Xue et al. 5 citations
In mechanically ventilated patients with ARDS, esketamine combined with midazolam improved respiratory system compliance and oxygenation compared with remifentanil combined with midazolam. At 72 hours after medication, static compliance was higher in the esketamine group (49.8 ± 13.8) than in the control group (42.4 ± 11.9), while plateau pressure and peak airway pressure were lower. Both groups received equivalent sedation and analgesia. The findings suggest esketamine may offer respiratory advantages in this population.