Effectiveness of ketamine/esketamine in alleviating postoperative fatigue: a systematic review
International Journal of Clinical Pharmacy November 12, 2025 Qijing Liu, Ying Liu, Qian Fu et al. 2 citations
Ketamine and esketamine may help reduce postoperative fatigue (POF), especially after major abdominal surgeries. However, this evidence is uncertain because the studies reviewed used different designs, measured fatigue in various ways and at different times, and had small numbers of participants. More rigorous randomized controlled trials are needed to confirm these effects and determine the best doses.