Effect of low-dose esketamine on postoperative quality of recovery in total laparoscopic hysterectomy: a randomized controlled trial.
Perioperative medicine (London, England) July 23, 2025 Jing Zhang, Zheng Niu, Ting Wang et al. 5 citations
In patients undergoing total laparoscopic hysterectomy, a single low dose of esketamine (0.25 mg/kg) given at anesthesia induction did not improve overall quality of recovery as measured by the QoR-40 questionnaire compared to saline. However, esketamine reduced intraoperative opioid use, stabilized blood pressure and heart rate, shortened time to extubation and recovery room stay, and lowered postoperative pain scores, inflammation, and sleep disturbance without causing adverse effects. Higher education level was associated with better recovery.