A case series of ibogaine toxicity reported to the United Kingdom National Poisons Information Service (NPIS) over a 10-year period.
Clinical toxicology (Philadelphia, Pa.) March 1, 2025 Ella P Edwards, Laurence A Gray, Muhammad E M O Elamin et al. 2 citations
Ibogaine, a psychoactive alkaloid from the West African shrub Tabernanthe iboga, is not licensed in the UK but is used by individuals to self-treat drug or alcohol use. A retrospective analysis of telephone enquiries to the UK National Poisons Information Service from 2012 to 2022 identified eleven enquiries about seven patients, all symptomatic and using ibogaine recreationally. Doses ranged from 5g to 34g. Seven patients had neurological symptoms and six had cardiotoxicity, including cardiac arrest, hypoxia, torsade de pointes, and QT prolongation. The findings indicate that ibogaine can cause severe cardiotoxicity and neurological harm, especially when used in variable, unregulated doses.