Tabernaemontana arborea and ibogaine induce paroxysmal EEG activity in freely moving mice: Involvement of serotonin 5-HT1A receptors.
Neurotoxicology March 1, 2022 María Eva González-Trujano, Felix Krengel, Ricardo Reyes-Chilpa et al. 14 citations
A hydroalcoholic extract of Tabernaemontana arborea and its alkaloids ibogaine and voacangine altered brain electrical activity in mice. The extract at 56.2 and 100 mg/kg and ibogaine at 30 mg/kg increased delta and reduced alpha EEG band power, indicating central nervous system depression. Voacangine at 30 mg/kg flattened EEG patterns. None of the treatments modified seizures induced by pentylenetetrazole, but the extract at 100 mg/kg combined with the convulsant caused sudden death. Paroxysmal EEG activity from the extract and ibogaine was explored; a serotonin 5-HT1A receptor antagonist blocked the extract's but not ibogaine's paroxysmal activity, implicating serotonin neurotransmission in the extract's excitatory effects.