Ibogaine Blocks Cue- and Drug-Induced Reinstatement of Conditioned Place Preference to Ethanol in Male Mice.
Frontiers in pharmacology January 1, 2021 Gabrielle M Henriques, Alexia Anjos-Santos, Isa R S Rodrigues et al. 10 citations
Ibogaine, a psychedelic from the African plant Tabernanthe iboga, blocked the reinstatement of a conditioned place preference for ethanol in male mice, suggesting it may disrupt learned alcohol-seeking behaviors. Ethanol (1.8 g/kg) induced a conditioned place preference, but ibogaine (10 or 30 mg/kg) did not produce rewarding effects on its own. Repeated ibogaine treatment after ethanol conditioning prevented reinstatement of the preference both when mice received a priming ethanol injection and when they were re-exposed to the ethanol-paired compartment without the drug. These results indicate ibogaine could have therapeutic potential for alcohol use disorder at doses that lack rewarding effects.