Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT.
Experimental neurology April 1, 2020 Jessica Winne, Barbara C Boerner, Thawann Malfatti et al. 34 citations
Salicylate intoxication, which causes tinnitus and anxiety in humans, induces anxiety-like behavior and a specific brain oscillation called type 2 theta (theta2) in the hippocampus of young mice with normal hearing, but not in older mice. A single dose of the hallucinogenic compound 5-MeO-DMT prevents both the anxiety-like behavior and the increase in theta2 and slow gamma oscillations in the ventral hippocampus and medial prefrontal cortex after salicylate injection. These findings suggest that the anxiety triggered by salicylate depends on normal hearing and that hallucinogenic compounds may be effective for treating tinnitus-related anxiety.