Behavioral effects of three synthetic tryptamine derivatives in rodents.
Journal of psychopharmacology (Oxford, England) April 4, 2025 Rebecca D Hill, Ritu A Shetty, Nathalie Sumien et al.
Three new synthetic tryptamines—5-MeO-DBT, 5-Cl-DMT, and 4-OH-MiPT—were tested in mice and rats for their effects on movement and their ability to mimic the hallucinogen DOM. All three produced depressant phases similar to DOM but were less potent. In rats trained to discriminate DOM, only 4-OH-MiPT fully substituted for DOM, suggesting it shares DOM's abuse potential, while 5-MeO-DBT and 5-Cl-DMT did not fully substitute and decreased response rates.