Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT.
Scientific reports October 9, 2017 Vanja Dakic, Juliana Minardi Nascimento, Rafaela Costa Sartore et al. 137 citations
5-MeO-DMT, a serotonin-like molecule found in traditional Amerindian medicine, alters the protein landscape of human cerebral organoids. Out of 6,728 identified proteins, 934 were differentially expressed after treatment. Computational analysis confirmed previously reported anti-inflammatory effects and revealed modulation of proteins involved in long-term potentiation, dendritic spine formation, cellular protrusion, microtubule dynamics, and cytoskeletal reorganization. These findings provide initial molecular insights into how this compound may affect human brain metabolism.