Ultra-high-pressure liquid chromatography tandem mass spectrometry determination of hallucinogenic drugs in hair of psychedelic plants and mushrooms consumers.
Journal of pharmaceutical and biomedical analysis November 1, 2014 Simona Pichini, Emilia Marchei, Oscar García-algar et al. 44 citations
A new laboratory method using ultra-high-pressure liquid chromatography tandem mass spectrometry can detect and measure mescaline, N,N-dimethyltryptamine, psilocin, psilocybin, and salvinorin A in hair from people who use psychedelic plants such as peyote, trichocereus cacti, psilocybe mushrooms, Salvia divinorum, or the beverage ayahuasca. The method is accurate and precise, with detection limits as low as 0.03–0.05 nanograms per milligram of hair. Testing on actual users found mescaline at 0.08–0.13 ng/mg in peyote smokers, 3.2 ng/mg salvinorin A in a Salvia divinorum smoker, 5.6 ng/mg N,N-dimethyltryptamine in an ayahuasca user, and 0.8 ng/mg psilocybin in a psilocybe consumer.