Skip to content

Petr Kačer

2 papers in the library · 56 citations · publishing 2013-2017

Papers

Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats.

Psychopharmacology January 1, 2013 Tomáš Páleníček, Michaela Fujáková, Martin Brunovský et al. 51 citations

The synthetic compound 2C-B produces a biphasic effect on movement in rats: initial inhibition followed by excitation, while amphetamine only causes hyperactivity. Both drugs disrupt prepulse inhibition of the acoustic startle reaction, a measure of sensory gating, but have opposite effects on the startle itself. 2C-B increases dopamine and decreases its metabolite DOPAC in the nucleus accumbens, a brain region linked to reward. Low doses of 2C-B reduce electrical brain activity and connectivity; a high dose first decreases then increases brain wave power and connectivity. Increases in theta and alpha brain waves correlate with heightened movement and dopamine levels. These results suggest 2C-B shares properties with hallucinogens, entactogens, and stimulants, and its dopamine effects may indicate psychotomimetic and addictive potential.

DOI: 10.1007/s00213-012-2797-7 Full text 2c-b Synthetic compound Substance Neurotransmitters +18

X-ray powder diffraction data for ( S )-Deschloroketamine hydrochloride, C 13 H 18 ClNO

Powder Diffraction June 21, 2017 J. Maixner, Bronislav Jurásek, Michal Kohout et al. 5 citations

The crystal structure of S-2-(methylamino)-2-phenylcyclohexan-1-one hydrochloride (C13H18ClNO) was determined using X-ray powder diffraction. The compound crystallizes in the monoclinic space group P21 with unit-cell parameters a = 6.578 Å, b = 13.250 Å, c = 15.096 Å, β = 91.619°, and a unit-cell volume of 1315 ų, with four formula units per cell. All measured diffraction lines were indexed and are consistent with the assigned space group, and no detectable impurities were observed in the sample.

DOI: 10.1017/s0885715617000586 Powder diffraction Group periodic table Hydrochloride Unit ring theory +9