Ibogaine interferes with motivational and somatic effects of naloxone-precipitated withdrawal from acutely administered morphine.
Progress in neuro-psychopharmacology & biological psychiatry February 1, 2002 Linda A Parke, Page Burton, Robert V Mcdonald et al. 17 citations
Ibogaine reduces both the physical signs and the motivational distress of opioid withdrawal in rats. In two experiments, rats given morphine only twice and then injected with naloxone to trigger withdrawal showed less aversion to a place associated with withdrawal and fewer physical withdrawal reactions when they had received ibogaine four hours earlier, compared with rats given saline. The results suggest ibogaine can interfere with withdrawal even after limited opioid exposure, targeting not just somatic symptoms but also the motivational aspects that make withdrawal distressing.