Determination of salvinorins and divinatorins in Salvia divinorum leaves by liquid chromatography/multistage mass spectrometry.
Rapid communications in mass spectrometry : RCM January 1, 2006 Claudio Medana, Cristina Massolino, Marco Pazzi et al. 35 citations
Salvinorin A, a neoclerodane diterpenoid from the mint-family plant Salvia divinorum, is the most potent naturally occurring hallucinogen known, rivaling synthetic LSD. It is the only non-nitrogenous kappa-opioid-selective agonist. The plant, used in ancient Mexican traditions, is now widely cultivated in Europe as a recreational marijuana substitute and is illegal in some countries. Six salvinorins and three divinatorins have been isolated from its leaves. Liquid chromatography/electrospray ionization multistage mass spectrometry (LC/ESI-MS(n)) is used for ion fragmentation, separation, and quantitation of these diterpenes, highlighting the role of LC in herbal extract analysis and MS(n) for diagnosing natural organic product classes.