Application of electrophysiological method to study interactions between ibogaine and cocaine.
Annals of the New York Academy of Sciences September 1, 2000 Z Binienda, M A Beaudoin, B T Thorn et al. 4 citations
Pretreatment with ibogaine dampens the brain's reaction to cocaine in rats. In awake adult male rats, cocaine alone caused a brief increase in alpha1 brain wave power and desynchronization in alpha2 and beta bands, along with a surge in dopamine levels in the caudate nucleus. After ibogaine pretreatment, cocaine instead produced a prolonged increase in delta, theta, and alpha1 power lasting up to an hour, and dopamine levels decreased further rather than rising. Dopamine turnover increased with ibogaine alone but not when cocaine followed. These changes in electrical brain activity and neurotransmitter levels indicate a reduced response to cocaine after ibogaine pretreatment.