Treatment of acute opioid withdrawal with ibogaine.
The American journal on addictions January 1, 1999 K R Alper, H S Lotsof, G M Frenken et al. 201 citations
In a review of 33 cases of ibogaine treatment for opioid detoxification in non-medical settings, 25 patients showed complete resolution of opioid withdrawal signs and cessation of drug-seeking behavior within 24 hours, sustained over 72 hours. Other outcomes included drug-seeking without withdrawal (4 patients), abstinence with attenuated withdrawal (2 patients), drug-seeking with continued withdrawal (1 patient), and one fatality possibly from surreptitious heroin use. The average daily heroin use was 0.64 grams, primarily intravenously. The findings suggest the need for systematic clinical research to confirm ibogaine's potential for rapidly alleviating severe opioid withdrawal.