Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity.
Psychopharmacology April 1, 1995 P M Sweetnam, J Lancaster, A Snowman et al. 109 citations
Ibogaine, an indole alkaloid being studied for treating cocaine and opioid addiction, interacts with a wide variety of neurotransmitter receptors and ion channels at concentrations of 1-100 microM. These include mu, delta, kappa opiate receptors, 5HT2, 5HT3, muscarinic1 and 2 receptors, and dopamine, norepinephrine, and serotonin uptake sites. It also affects NMDA-associated ion and sodium ion channels. This broad spectrum of activity may partly explain ibogaine's potential anti-addictive properties, though a clearly defined molecular mechanism has not been established.